Authors: Wang P, et al.
Title: Low incidence of lamotrigine treatment-emergent rash with dermatology precautions.
Reference: APA 2004, New Research Presentation.
Purpose: To assess the rate of rash in bipolar patients initiating lamotrigine therapy using Stanford Dermatology Precautions (not started within 2 weeks of rash, viral syndrome, or vaccination. During first 3 months: no new medicines, foods, cosmetics, detergents, etc.).
Study design: Retrospective chart review.
Follow up: Minimum of 3 months (mean 8.4 months).
Patients: 100 bipolar patients.
Treatment: Lamotrigine monotherapy or add-on therapy using standard titration.
Results: There were no cases of serious rash observed. The rate of non-serious rash was 5% in all patients, but only 2% in patients adherent to dermatology precautions. The overall discontinuation rate (for any reason) was only 8% during the first 3 months of treatment.