| | Risperidone monotherapy for acute mania (1)
Authors: Vieta, et al.
Title: Risperidone in the treatment of manic or mixed episodes of bipolar disorder.
Reference: Poster presented at the 41st ACNP annual meeting, December 2002.
Purpose: To determine the efficacy of risperidone monotherapy in the acute treatment of patients with manic or mixed episodes.
Study design: Randomized, double-blinded, placebo-controlled, 3-week, multicenter trial conducted in India.
Follow up: none specified.
Patients: 290 bipolar I inpatients (146 risperidone, 144 placebo) with a manic or mixed episode (YMRS >20).
Treatment: Risperidone flexible dose (1–6 mg/day) or placebo monotherapy.
Results: Risperidone produced significantly greater improvements in YMRS scores compared with placebo from week 1 onwards. At the endpoint, response rates (>50% reduction in YMRS) were 73% for risperidone and 36% for placebo (p < 0.001). Symtoms of EPS were reported in 35% of risperidone-treated patients versus 6% of placebo-treated patients.
extra-pyramidal symptoms Young Mania Rating Scale Young Mania Rating Scale Young Mania Rating Scale American College of Neuropsychopharmacology American College of Neuropsychopharmacology American College of Neuropsychopharmacology American College of Neuropsychopharmacology American College of Neuropsychopharmacology
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