Authors: Yocca et al.
Title: Efficacy of aripiprazole in acute mania: a new acute placebo-controlled study.
Reference: European College of Neuropsychopharmacology 2003. [Congress poster]
Purpose: To compare the efficacy and safety of aripiprazole with those of placebo for the treatment of patients in an acute manic or mixed episode of bipolar disorder. 
Study design: Randomized, double-blinded, placebo-controlled, multicenter study. 
Follow up: 3 weeks. 
Patients: 272 patients (135 aripiprazole, 137 placebo). 
Treatment: Aripiprazole 30 mg/day (reduced to 15 mg/day if needed for tolerability) or placebo. 
Results: There were significant improvements in the mean total YMRS score of patients treated with aripiprazole compared with patients treated with placebo. Aripiprazole was well tolerated.