• Potentially effective as add-on therapy in the long-term management of patients with bipolar disorder.
• Potentially effective as add-on therapy to promote weight loss. 

GSK counterclaims

• There are no controlled data to support the use of topiramate. 
• Numerous failed/negative bipolar studies have been conducted by the sponsor (Janssen). 
• Topiramate is not registered for use in bipolar disorder.

Supporting data