|
|
 | | | | | | | Paroxetine and switching
Authors: Morishita S and Arita S.
Title: Induction of mania in depression by paroxetines.
Reference: Hum Psychopharmacol Clin Exp 2003;18:565-8.
Purpose: To identify predictors of a switch to mania in depressed patients treated with paroxetine.
Study design: Retrospective chart review.
Follow up: Variable.
Patients: 79 depressed outpatients (unipolar, pseudo-unipolar, or bipolar depression).
Treatment: Paroxetine 10–40 mg/day.
Results: Switching to mania occurred in 9% of patients treated with paroxetine. Bipolar depression (odds ratio = 20) and family history of psychiatric illness (odds ratio = 11) were associated with a greater risk of switching.
| | | |
|
