Olanzapine vs divalproex: mania and maintenance Author: Tohen, et al. Title: Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47 week study. Reference: Am J Psychiatry 2003;160:1263–71. Purpose: Long-term efficacy of olanzapine versus divalproex. Study design: Randomized, double-blinded trial. Follow up: 47 weeks. Patients: 251 (125 olanzapine; 126 divalproex). Treatment: Olanzapine 5–20 mg/day or divalproex 500–2,500 mg/day. Results: Olanzapine had greater efficacy than divalproex for the treatment of acute mania. However, the drugs had similar efficacy for the prevention of relapse. Weight gain was greater in patients receiving olanzapine compared with those receiving divalproex (3.44 kg versus 1.72 kg).
