Authors: Bowden C, et al.
Title: Concomitant use of lamotrigine with lithium or valproate in bipolar I disorder.
Reference: World J Biol Psychiatry 2004;5(Suppl 1):48. 
Purpose: To evaluate the efficacy and safety of lamotrigine and lithium, and lamotrigine and valproate, in patients with bipolar disorder.
Study design: Pooled data from the preliminary open-label phase of two large maintenance trials.
Follow up: 8–16 weeks.
Patients: 492 (292 lamotrigine and lithium, 200 lamotrigine and valproate).
Treatment: Not specified.
Results: Improvement of mean CGI-S and GAS scores was observed with either combination therapy. Concomitant administration seemed to be effective. Combination therapy was well-tolerated and the most common adverse events were headache, nausea, diarrhea, infection, and rash. No cases of serious rash were reported. No significant differences in rash were observed with or without combination treatment with valproate.

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