OLANZAPINE        NO TREATMENT-EMERGENT MANIA 
Reduced relapse rate
Longer time to relapse
At least as effective as lithium
OFC in bipolar depression
No treatment-emergent mania
Supporting data
Improvements in HR-Qol
Fewer drop-outs than lithium
No QTc prolongation
Usage
Supported by GSK.
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 No treatment-emergent mania

Does not increase risk of treatment-emergent mania in depressed bipolar patients

During an 8-week trial of olanzapine and OFC in bipolar I depressed patients, OFC and olanzapine did not increase the risk of treatment-emergent mania.

GSK counterclaim:

Depression is consistently among the most frequently observed side effects with olanzapine maintenance treatment (Supporting data 3 and 4).
olanzapine fluoxetine combination
olanzapine fluoxetine combination
olanzapine fluoxetine combination


  
 Supporting trials
- OFC in bipolar depression
- Rate of treatment-emergent mania with OFC
- Olanzapine for maintenance of bipolar disorder
- Olanzapine vs lithium for prevention of relapse

 
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